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This condition also induces an increase in several inflammatory mediators, including the protein levels and mRNA expression of TLR-4, NF-κB, p65, and p38 MAPK, as well as elevated levels of proinflammatory cytokines such as IL-1β, ICAM-1, and TNF-α [ 51 , 52 ]

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doi: 10.1016/j.neuroscience.2018.08.032 143 ZhouJ